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A double‐blind trial of treatment of seborrhoeic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream
Author(s) -
KATSAMBAS A.,
ANTONIOU CH.,
FRANGOULI E.,
AVGERINOU G.,
MICHAILIDIS D.,
STRATIGOS J.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01429.x
Subject(s) - ketoconazole , seborrhoeic dermatitis , hydrocortisone , medicine , dermatology , double blind , incidence (geometry) , antifungal , placebo , mathematics , pathology , alternative medicine , geometry
SUMMARY Fifty patients with seborrhoeic dermatitis were treated with 2% ketoconazole cream ( n =24) or with 1% hydrocortisone cream ( n =26) for 4 weeks in a double‐blind comparative study. These twice daily applications resulted in 87.2% symptomatic improvement for hydrocortisone vs. 81.6% for ketoconazole. The number of P. ovale yeasts was significantly reduced after the application of ketoconazole compared with hydrocortisone. The incidence of side‐effects was low in both groups.