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Complement C 3 proteins in psoriasis
Author(s) -
ACEVEDO F.,
HAMMAR H.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01426.x
Subject(s) - psoriasis , complement (music) , medicine , dermatology , immunology , complement system , computational biology , biology , antibody , genetics , phenotype , complementation , gene
SUMMARY A new polymorphism of the complement factor C3 in human plasma was demonstrated by isotachophoresis in agarose gels followed by immunodetection with rabbit anti‐human C3 c and C3 d immunoglobulins. Four bands were detected in the immunoprint of freshly drawn EDTA‐plasma, which were C3 s1 , C3 s2 , C3 f1 and C3 f2 . At least four additional C3 components in Mg 2+ ‐zymosan activated plasma were present, which were C3 b1 to C3 b4 . The different forms of C3 in frozen and thawed heparin‐plasma from 20 patients with psoriasis and 20 healthy individuals were studied from the immunoprint. The total content of C3 components was 29% greater in the patients with psoriasis than controls. The major difference was in the C3 b components which were increased by 46%. In psoriatic patients, the two slow C3 components C3 s1 and C3 s2 were increased by 24 and 56% respectively, when compared with controls. The two fast C3 components C3 f1 and C3 f2 were decreased to 29 and 37%. The results suggest a direct involvement of the complement factor C3 in psoriasis.