Premium
Arachidonic acid transformation is not stimulated in delayed pressure urticaria
Author(s) -
LAWLOR FRANCES,
BARR R.,
KOBZAEBLACK ANNE,
CROMWELL O.,
ISAASCS JUNE,
GREAVES M.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01424.x
Subject(s) - arachidonic acid , medicine , transformation (genetics) , endocrinology , chemistry , biochemistry , gene , enzyme
SUMMARY Little is known about the molecular mechanisms or inflammatory mediators involved in delayed pressure urticaria (DPU). Pressure sufficient to provoke lesions was applied to the back of six patients with DPU. The levels of products of arachidonic acid transformation in skin exudate from the pressure challenged skin were estimated immediately after pressure was removed and 6 h later when lesions were present. These were compared to levels estimated in a similar way from unchallenged skin in these patients. Levels of leukotriene C 4 /D 4 /E 4 , prostaglandin E 2 , 12‐hydroxyeicosatetraenoic acid and leukotriene B 4 were not raised in lesional skin. Our results suggest that arachidonic acid metabolism is not stimulated in DPU.