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Antibodies to Ro/SSA detected by ELISA: correlation with clinical features in systemic scleroderma
Author(s) -
BELL SUSANNE,
KRIEG T.,
MEURER M.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01397.x
Subject(s) - scleroderma (fungus) , polymyositis , medicine , systemic scleroderma , antibody , sicca syndrome , rheumatoid factor , systemic disease , immunology , anti nuclear antibody , autoantibody , immunopathology , dermatomyositis , disease , inoculation
SUMMARY Anti‐Ro/SSA antibodies were determined by a newly developed enzyme‐linked immunosorbent assay in serum specimens from 114 patients with systemic scleroderma in order to examine the relationship between Ro/SSA antibodies and clinical subsets of scleroderma. Sera of 42 patients (37%) were positive for Ro/SSA antibodies. Clinical investigations, including Schirmer's test and enzymatic profiles, demonstrated that 60% (16 of 27) of scleroderma patients with sicca syndrome and 63% (10 of 16) with polymyositis (PM) were Ro/SSA positive. In these patients there was a significant association between Ro/SSA antibodies and rheumatoid factor. HLA‐antigens DR2, DR3 and B8 showed an increased frequency in anti‐Ro/SSA positive patients.