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Release of prostacyclin from cultured human endothelial cells following prolonged exposure to histamine
Author(s) -
BULL HELEN A.,
RUSTIN M.H.A.,
DOWD PAULINE M.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01373.x
Subject(s) - prostacyclin , histamine , medicine , pharmacology , chemistry , endocrinology
SUMMARY Histamine is an important pro‐inflammatory molecule mediating leukocyte margination, plasma extravasation and vasodilation, but its precise mode of action on vascular endothelium is unclear. We report that histamine is able to induce prolonged release of prostacyclin (PGI 2 ) from human endothelial cells via occupancy of the H 1 receptor, without an absolute requirement for the presence of histamine or synthesis of new enzyme protein to facilitate continued release of PGI 2 .