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Non‐symmetric subcutaneous lipomatosis associated with familial combined hyperlipidaemia
Author(s) -
RUBINSTEIN A.,
GOOR Y.,
GAZIT E.,
CABILI S.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01357.x
Subject(s) - lipomatosis , medicine , subcutaneous fat , cholesterol , endocrinology , haplotype , allele , biology , genetics , pathology , gene , adipose tissue
SUMMARY A family with familial combined hyperlipidaemia in which affected members had non‐symmetric subcutaneous lipomatosis (NSSCL) is described. Affected members had high serum levels of total cholesterol, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol. By contrast, family members without NSSCL had normal lipid levels. There was also a correlation between the degree of hyperlipidaemia and the amount of subcutaneous lipomas. The occurrence of hyperlipidacmia in family members with NSSCL suggests the existence of a genetic linkage between these two characteristics, but did not show any association with HLA haplotyping. To our knowledge this association between lipid abnormalities and NSSCL has not been previously reported.