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Calcitonin gene‐related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta
Author(s) -
VAALASTI ANNIKKI,
SUOMALAINEN HANNA,
RECHARDT LEENA
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01346.x
Subject(s) - prurigo nodularis , prurigo , neurodermatitis , medicine , calcitonin gene related peptide , calcitonin , substance p , itching , dermatology , neuropeptide , nerve fiber , pathology , anatomy , receptor
SUMMARY Eight patients with intensely pruritic lesions of chronic idiopathic prurigo nodularis and three patients with neurodermatitis circumscripta were investigated using the indirect immunofluoresence method. Results showed similarities in epidermal hyperplasis but not in nerve proliferation and neuropeptide immunoreactivity. Increased numbers of calcitonin generelated peptide (CGRP) and substance P immunoreactive nerve fibre bundles were detected in specimens taken from prurigo nodularis lesions, but no increased immunoreactivity could be seen in specimens taken from patients having neurodermatitis circumscripta compared to normal skin. The neuropeptides, CGRP and substance P, may be responsible for the intense itching of prurigo nodularis lesions.