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Intercellular adhesion molecule‐1 (ICAM‐1) expression correlated to inflammation
Author(s) -
LISBY S.,
RALFKIAER E.,
ROTHLEIN R.,
VEJLSGAARD G.L.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01320.x
Subject(s) - psoriasis , intercellular adhesion molecule 1 , icam 1 , peripheral blood mononuclear cell , inflammation , medicine , puva therapy , cell adhesion molecule , keratinocyte , intercellular adhesion molecule , pathology , intracellular , immunology , adhesion , cell adhesion , biology , chemistry , cell culture , in vitro , microbiology and biotechnology , biochemistry , genetics , organic chemistry
SUMMARY The presence of intercellular adhesion molecule‐1 (ICAM‐1) on keratinocytes of psoriatic skin lesions before and during 8‐methoxapsoralen and UVA light (PUVA) treatment was studied. ICAM‐1 was expressed on the keratinocytes in biopsies of the skin lesions of five patients with psoriasis. The patients who responded to PUVA treatment had a concurrent reduction of ICAM‐1 expression on the keratinocytes with a reduction of the number of cells in the mononuclear cellular infiltrate and a lessening of the severity of the disease. Patients who went into remission during therapy and then relapsed showed an increase in ICAM‐1 expression on keratinocytes with an increase in the number of cells in the mononuclear cell infiltrate and an increase in the severity of the disease. HLA‐DR expression on keratinocytes was variable during treatment and showed no strong correlation with disease severity.