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Effect of isotretinoin on eccrine gland function
Author(s) -
REES J.L.,
COX N.H.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb07105.x
Subject(s) - pilocarpine , isotretinoin , sweat , iontophoresis , medicine , sweat gland , endocrinology , confidence interval , secretion , dermatology , acne , psychiatry , epilepsy , radiology
SUMMARY Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t‐test; 95% confidence limits—0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.