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A study of local immunity in psoriasis
Author(s) -
RAMIREZBOSCA ANA,
MARTINEZOJEDA L.,
VALCUENDECAVERO FRANCISCA,
CASTELLSRODELLAS A.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb03469.x
Subject(s) - psoriasis , immunity , medicine , immunology , dermatology , immune system
SUMMARY We have studied biopsies of lesional skin with monoclonal and polyclonal antibodies to determine the nature of the infiltrate in different forms of psoriasis. In guttate psoriasis the number of Langerhans cells (LC) was not increased and CD8 + cells predominated, however, most CD 4 + cells were activated. In erythrodermal psoriasis some CD1 + cells were found in the dermis although CD8 + cells predominated and were activated. In palmo‐plantar psoriasis LC were found in the epidermis and superficial dermis and CD 4 + cells were more numerous than CD8 + cells, some in turn expressing HLA‐DR. In flexural psoriasis the LC formed clusters in the epidermis, and activated CD 4 + cells predominated. In psoriasis vulgaris CD 4 + cells predominated over CDS + although the latter were activated. Our observations tend to support Valdimarsson's hypothesis on the immune basis of psoriasis, but we believe that two cycles coexist in psoriasis—one inflammatory and the other immunological—and that interaction between these leads to epidermal hyperproliferation.