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Intestinal mucosal mast cells: enumeration in urticaria pigmentosa and systemic mastocytosis
Author(s) -
FERGUSON J.,
THOMPSON R. P. H.,
GREAVES M. W.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb03467.x
Subject(s) - urticaria pigmentosa , systemic mastocytosis , cutaneous mastocytosis , enumeration , medicine , mast cell , immunology , mast (botany) , mathematics , combinatorics
SUMMARY Endoscopic gastrointestinal mucosal biopsy specimens from one patient with systemic mastocytosis and five with urticaria pigmentosa (UP) were fixed with Carney's reagent and then stained for chloracetate esterase. The mast cell population densities were enumerated in the mucosa using cursor planimetry. Compared with controls, mast cell counts were increased in gastric and duodenal but not sigmoid mucosae. On a histological basis, systemic involvement would appear commoner in urticaria pigmentosa than is generally expected. Gastrointestinal symptoms did not relate to elevated mucosal mast cell counts.