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In vivo effects of interferon‐γ and anti‐interferon‐γ antibody on the experimentally induced lichenoid tissue reaction
Author(s) -
SHIOHARA T.,
NICKOLOFF B. J.,
MORIYA N.,
GOTOH C.,
NAGASHIMA M.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb03202.x
Subject(s) - medicine , dermatology , family medicine , library science , computer science
SUMMARY We investigated the in vivo effect of recombinant interferon‐γ (IFN‐γ) and tumour necrosis factor α (TNF‐α) treatment of mice on the development of the delayed‐type hypersensitivity (DTH) reaction and lichenoid tissue reaction (LTR) following the local injection of cloned autoreactive T cells. Both the DTH reaction and the LTR were significantly enhanced by pre‐treatment with IFN‐γ, but not with TNF‐ã. Induction of class II MHC antigens on keratinocytes was not essential for the enhancement by IFN‐γ. Administration of anti‐IFN‐γ antibody reduced the DTH reaction and LTR, although complete inhibition was not observed with our treatment regimen. The ability of IFN‐γ to increase the number of the cloned T cells invading the epidermis in vivo , is in keeping with our previous observation that IFN‐γ treatment of cultured keratinocytes markedly increased the adherence reaction between T cells and keratinocytes in vitro.