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A clinicopathological study of mucosal involvement in linear IgA disease
Author(s) -
KELLY SUSAN E.,
FRITH PEGGY A.,
MILLARD P. R.,
WOJNAROWSKA FENELLA,
BLACK M. M.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb03197.x
Subject(s) - conjunctiva , basement membrane , medicine , immunofluorescence , pathology , disease , immunoglobulin a , mucous membrane , direct fluorescent antibody , oral mucosa , indirect immunofluorescence , immunology , antibody , immunoglobulin g
SUMMARY Mucosal involvement in linear IgA disease was assessed clinically and immunologically using direct and indirect immunofluorescence (IF) techniques. There was clinical evidence of oral mucosal involvement in all 10 patients examined and conjunctival disease in six. Direct IF findings correlated well with clinical oral disease, with all patients demonstrating linear IgA deposits in the basement membrane zone of oral mucosa, However, this was not true of conjunctiva where no linear IgA could be demonstrated. Conjunctiva did provide a good substrate for indirect immunofluorescence using patients' sera, and showed that five of the ro patients had circulating anti‐basement membrane zone IgA.