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Monochloroacetic acid and 60% salicylic acid as a treatment for simple plantar warts: effectiveness and mode of action
Author(s) -
STEELE K.,
SHIRODARIA P.,
O'HARE M.,
MERRETT J.D.,
IRWIN W.G.,
SIMPSON D.I.H.,
PFISTER H.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb02464.x
Subject(s) - plantar warts , salicylic acid , placebo , medicine , immune system , human papilloma virus , gastroenterology , antibody , surgery , dermatology , immunology , pathology , chemistry , cervical cancer , biochemistry , alternative medicine , cancer
SUMMARY Monochloroacetic acid crystals and 60% salicylic acid ointment was found to be more effective than placebo as a treatment for simple plantar warts in a double blind study on 57 patients. Nineteen (66%) patients in the active treatment group compared with five (18%) patients in the placebo group were cured after 6 weeks ( P = 0.002). The active treatment was associated with a significantly higher cure rate 6 months after entry ( P = 0.04). Treatments were well tolerated. IgG or IgM antibodies or both to human papilloma virus (HPV) types 1 or 2 or both were detected significantly more frequently in the actively treated group 6 weeks after entry ( P = 0.0005). Twelve (50%) patients considered to be cured had no detectable secondary immune response. Our results suggest that cure does not depend primarily on the humoral system but rather on mechanical destruction of wart tissue, or occurs as a result of cell mediated immunity.