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Genetic control of sebum excretion and acne—a twin study
Author(s) -
WALTON SHERNAZ,
WYATT E.H.,
CUNLIFFE W.J.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb02433.x
Subject(s) - acne , excretion , medicine , dermatology , endocrinology
SUMMARY Sebum excretion and acne grades were measured in 20 pairs each of identical and non‐identical like‐sex twins. The identical twins had virtually identical rates of sebum excretion (P > 0·05), but they had a significantly different degree of acne severity (P < 0·01). The non‐identical twins had significantly different sebum excretion rates (P > 0·01) and acne grades (P < 0·01). These findings suggest that sebum excretion is under genetic control and the development of clinical lesions is modified by environmental factors.