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Ro/SSA antigen in human epidermis
Author(s) -
JONES S.K.,
COULTER SILVIJA,
HARMON CATHERINE,
NORRIS D.A.,
ROSANDICH MARY,
LEE LELA A.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb02429.x
Subject(s) - administration (probate law) , medicine , library science , history , family medicine , political science , law , computer science
SUMMARY It has been shown previously by an immunofluorcscence technique, that whole serum from patients who have anti‐Ro/SSA autoantibodies reacts with a component or components of the epidermis. We have now demonstrated by immunoblotting that the antigen identified in human epidermis by anti‐Ro/SSA sera is Ro/SSA antigen, and that Ro/SSA antigen is present both in adult and in neonatal epidermis. The presence of this antigen in tissues which are injured in the anti‐Ro/SSA‐associated syndromes subacute cutaneous lupus erythematosus and neonatal lupus erythematosus supports the hypothesis that anti‐Ro/SSA antibodies react with Ro/SSA antigen in the skin and are important in the initiation of tissue damage.