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Pharmacological modulation of cold‐induced pain in cutaneous leiomyomata
Author(s) -
ARCHER C.B.,
WHITTAKER S.,
GREAVES M.W.
Publication year - 1988
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1988.tb01783.x
Subject(s) - square (algebra) , medicine , general hospital , university hospital , general surgery , family medicine , geometry , mathematics
summary In two patients with painful cutaneous leiomyomata, induction of pain by the application of an ice cube allowed assessment of a number of topical and systemic treatments aimed at reducing or preventing the pain. In one patient the alpha‐adrenoceptor blocker, phenoxybenzamine alleviated cold‐induced pain. In the second patient, topical 9% hyoscine hydrobromide (an anticholinergic agent) decreased pain induced by the ice cube, but was not helpful in reducing lesional pain due to cold weather.