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Leukotriene B 4 fails to induce penetration of lymorphonuclear leukocytes into psoriatic lesions
Author(s) -
LAMMERS A.M.,
KERKHOF P.C.M.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb07484.x
Subject(s) - medicine , dermatology , library science , computer science
SUMMARY The intraepidermal accumulation of polymorphonuclear leukocytes following the epicutaneous application of leukotriene B 4 (LTB 4 ) was studied in lesional and clinically uninvolved skin of five patients with chronic stable plaque psoriasis. The lesions were found to be wholly unresponsive to LTB 4 , doses of 100 ng failing to produce either micropustules or exocytosis. This phenomenon was sharply localized; the response immediately adjacent to the lesion being identical to that in more distant uninvolved skin. We speculate that both the reduced response to LTB 4 in the psoriatic patient and also the tolerance to LTB 4 seen after repeated applications, result from the induction of a P 450 ‐linked hydroxylase.