Premium
Natural killer cell activity of peripheral blood mononuclear cells from patients with various forms of lupus erythematosus
Author(s) -
BŁASZCZYK MARIA,
MAJEWSKI S.,
WASIK MARIA,
CHORZELSKI T.,
JABŁONSKA STEFANIA
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb07350.x
Subject(s) - medicine , library science , dermatology , classics , history , computer science
summary Natural killer (NK) cell activity of peripheral blood mononuclear cells from 28 patients with cutaneous discoid lupus erythematosus, seven with subacute cutaneous lupus erythematosus, and 17 with systemic lupus erythematosus was studied using a 4 h 51 Cr release assay using K‐562 cells as target cells. NK cell activity was found to be markedly decreased not only in patients with systemic lupus erythematosus but also in a proportion of cases of subacute cutaneous lupus erythematosus and cutaneous discoid lupus erythematosus (57% and 39% respectively). There was a relationship between the activity and severity of LE and the decrease in NK cell activity.