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Reduction of leukotriene B 4 ‐induced intraepidermal accumulation of polymorphonuclear leukocytes by methotrexate in psoriasis
Author(s) -
LAMMERS A. M.,
KERKHOF P. C. M.,
MIER P. D.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05900.x
Subject(s) - methotrexate , leukotriene b4 , psoriasis , medicine , elastase , pharmacology , granulocyte , drug , infiltration (hvac) , dose , immunology , leukotriene c4 , neutrophil elastase , leukotriene , inflammation , chemistry , enzyme , biochemistry , physics , asthma , thermodynamics
SUMMARY The leukotriene B 4 (LTB 4 )‐induced intraepidermal accumulation of polymorphonuclear leukocytes (PMN) was quantified, using an elastase assay, in psoriatic patients receiving methotrexate and in untreated psoriatic patients. Methotrexate in therapeutic dosages inhibited PMN infiltration in six patients who had improved considerably on treatment with the drug, a gradual increase being seen during the days on which no methotrexate was taken. Two patients were in relapse, despite methotrexate treatment, and both failed to show any change in LTB 4 ‐induced accumulation of PMN.