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Etretinate‐induced skeletal muscle damage
Author(s) -
HODAK EMMILIA,
DAVID M.,
GADOTH N.,
SANDBANK MIRIAM
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05894.x
Subject(s) - etretinate , psoriasis , skeletal muscle , medicine , dermatology , pathology , necrosis , anatomy
SUMMARY Three patients who received etretinate, two for psoriasis vulgaris and one for exfoliative dermatitis, developed clinical and electromyographic features of muscle damage during treatment. In one patient histological and ultrastructural findings indicated segmental muscle necrosis. Withdrawal of the drug led to clinical recovery and normalization of muscle enzyme levels and electromyogram. To the best of our knowledge, this is the first report to show etretinate‐induced reversible skeletal muscle damage.