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Adult linear IgA bullous dermatosis with bronchial involvement
Author(s) -
VERHELST F.,
DEMEDTS M.,
VERSCHAKELEN J.,
VERBEKEN E.,
MARIËN K.,
PEETERS C.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05884.x
Subject(s) - medicine , pathology , respiratory system , calcification , direct fluorescent antibody , immunofluorescence , antibody , anatomy , immunology
SUMMARY A 54‐year‐old man is described, suffering from adult linear IgA bullous dermatosis with involvement of the bronchial mucosa. The main respiratory symptoms were recurring haemoptysis, episodic narrowing of the airways and persistant non‐specific bronchial hyper‐reactivity. On CT scan the trachea had a saber‐sheath shape with tracheal ring calcification. Endoscopically the trachco‐bronchial mucosa was diffusely purpuric and hyperaemic and also showed pale elevated plaques, bullous lesions and ulceration. Histological examination of biopsies of skin and nasal and tracheo‐bronchial mucosa showed subepithelial blister formation associated with an accumulation of polymorphonuclear cells at the epithelial‐subcpithelial junction, and linear IgA deposits on direct immunofluorescence.