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Response of polymorphonuclear leukocytes to topical leukotriene B 4 in healthy and psoriatic skin
Author(s) -
LAMMERS A.M.,
KERKHOF P.C.M.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05872.x
Subject(s) - leukotriene b4 , elastase , medicine , psoriasis , infiltration (hvac) , immunology , leukotriene , neutrophil elastase , neutrophile , granulocyte , inflammatory response , inflammation , enzyme , chemistry , biochemistry , physics , asthma , thermodynamics
SUMMARY The in situ infiltration of polymorphonuclear leukocytes following the topical application of leukotriene B 4 to the clinically uninvolved skin of psoriatic patients and the skin of normal controls has been quantified using elastase as a marker enzyme. The magnitude of this response in the psoriatic patients proved to be significantly diminished compared with the response in the controls. The time course of the response was similar in both groups, maximum elastase activity being seen about 18 h after application of the LTB 4 .