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Fixed drug eruption: an immunohistochemical investigation of the acute and healing phase
Author(s) -
HINDSÉN MONICA,
CHRISTENSEN OLE B.,
GRUIC VINKA,
LÖFBERG HELGE
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05849.x
Subject(s) - drug eruption , monoclonal antibody , immunohistochemistry , cytotoxic t cell , immunology , drug , antibody , medicine , pathology , biology , in vitro , pharmacology , biochemistry
SUMMARY Five patients were each challenged orally with a drug which had previously induced a fixed drug eruption. A positive reaction occurred in all the patients. Punch biopsies were taken 6–12 h, 24h and 3 weeks after challenge. The specimens were tested with different mouse anti‐human monoclonal antibodies to identify T lymphocytes and phenotypic subsets, natural killer cells, B lymphocytes, OKT‐6 and HLA‐DR‐positive cells. T suppressor/cytotoxic cells seemed to play a major role in initiating the flare‐up reaction and preserving the cutaneous memory function of the fixed drug eruption.