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Trimethoprim associated fixed drug eruption
Author(s) -
HUGHES BRONWYN R.,
HOLT P.J.A.,
MARKS R.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb05819.x
Subject(s) - drug eruption , trimethoprim , medicine , dermatology , drug , hyperpigmentation , dapsone , antibiotics , pharmacology , microbiology and biotechnology , biology
SUMMARY We report two cases of fixed drug eruption due to trimethoprim. Fixed drug eruption is a distinct entity characterized by the development of circular erythematous skin lesions which over a period of time become violaceous and leave an area of hyperpigmentation. Mucous membranes also may be affected. 1 With re‐administration of the drug the lesions recur in the same area but may extend to further new areas with each challenge. 2