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Involucrin expression in keratinization disorders of the skin—a preliminary study
Author(s) -
KANITAKIS J.,
ZAMBRUNO G.,
VIAC J.,
THIVOLET J.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04928.x
Subject(s) - involucrin , epidermolytic hyperkeratosis , ichthyosis vulgaris , palmoplantar keratoderma , ichthyosis , keratin , lamellar ichthyosis , epidermis (zoology) , dermatology , hyperkeratosis , filaggrin , pathology , darier's disease , papillomatosis , biology , acanthosis , keratoderma , medicine , keratinocyte , disease , atopic dermatitis , genetics , anatomy , in vitro
SUMMARY We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin‐biotin‐peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (6o%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congential bullous (58%) and non‐bullous (44%) ichythyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X‐linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin exression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.