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β 2 Microglobulin expression in keratoacanthomas and squamous cell carcinoma
Author(s) -
GRAHAM R.M.,
MACFARLANE A.W.,
CURLEY R.K.,
NASH J.R.G.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04923.x
Subject(s) - beta 2 microglobulin , malignancy , keratoacanthoma , basal cell , cell , pathology , expression (computer science) , medicine , cancer research , biology , immunology , genetics , computer science , programming language
SUMMARY The eell surface expression of beta‐2‐microglobulin (ß 2 M) was investigated in 33 keratoacanthomas (KA) and 58 squamous cell carcinomas (SCC) to determine whether this antigen was expressed to a different extent in these two conditions and, thus, whether this constitutes a reliable and practical test for distinguishing them. Loss of ß 2 M expression was not a reliable feature for distinguishing between KA and SCC and seemed to be related more to the degree of cellular differentiation and maturation, than to malignancy as such.