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Distribution of natural killer cells and lymphocyte subclasses in Jessner's lymphocytic infiltration of the skin and in cutaneous lesions of discoid and systemic lupus erythematosus
Author(s) -
VILJARANTA SATU,
RANKI ANNAMARI,
KARINIEMI ARJALEENA,
NIEMINEN P.,
JOHANSSON LEIJA
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04902.x
Subject(s) - lymphocytic infiltration , medicine , discoid lupus erythematosus , infiltration (hvac) , lymphocyte , pathology , immunology , cellular infiltration , immunopathology , lupus erythematosus , antibody , inflammation , physics , thermodynamics
SUMMARY We studied the cell infiltrates in biopsies from lymphocytic infiltration of the skin (LIS), with six monoclonal T cell antigen‐specific antibodies and compared the reactivity pattern with those in biopsies from discoid and systemic lupus erythematosus skin lesions and allergic contact skin reactions. A newly described antibody (NK 9 ) recognizing natural killer (NK) cells and activated cytotoxic T lymphocytes was included, and the numbers and activity of circulating NK cells was determined. Immunohistochemical staining revealed that the numbers of NK 9 ‐positive cells were highest in LIS. The distribution of T lymphocytes (OKT ii + ve), helper T cells (OKT 4 + ve), suppressor T celts (OKT8 + ve), Langerhans cells (OKT6 + ve) and activated T cells (anti‐Tac + ve) in LIS differed from those in DLE, SLE and allergic contact reactions. However, the number of circulating NK cells (large granular lymphocytes) and the NK activity in peripheral blood were normal in LIS. We conclude that in LIS a distinct type of T cell activation occurs; the cause of this remains to be determined.