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In vitro dissolution rates of six 8‐methoxypsoralen formulations
Author(s) -
STOLK L.M.L.,
PASMAN A.,
CORMANE R.H.,
ZWEITEN P.A.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04900.x
Subject(s) - dissolution , polyethylene glycol , capsule , chromatography , psoralen , dissolution testing , dosage form , methoxsalen , chemistry , pharmacology , medicine , dermatology , organic chemistry , biology , biochemistry , dna , botany , biopharmaceutics classification system , psoriasis
SUMMARY Dissolution rates in water of six oral 8‐methoxypsoralen formulations were determined with both the rotating basket method and a column type flow‐through method. Comparable and reproducible results were obtained with both methods. In view of the necessity in psoralen UVA (PUVA) therapy that effective tissue concentrations of the drug be present in the skin during the irradiation period, we propose a requirement for a dissolution rate of 8‐MOP tablets or capsules of at least 80% within 25 min. None of the three preparations registered in The Netherlands met this requirement. However, two preparations from abroad and a new capsule formulated in our pharmacy department with solid 8‐MOP dispersed in polyethylene glycol 6000 showed satisfactory dissolution profiles.