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Polymorphonuclear leukocyte function in psoriasis vulgaris
Author(s) -
PEASE C.T.,
FENNELL M.,
STAUGHTON R.C.D.,
BREWERTON D.A.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04112.x
Subject(s) - psoriasis , polymorphonuclear leukocyte , zymosan , chemotaxis , immunology , in vitro , agarose , medicine , granulocyte , neutrophile , chemistry , inflammation , biochemistry , receptor
SUMMARY Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age‐ and sex‐matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F–Met–Leu‐fPhe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis.