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Herpes gestationis factor reacts with the amniotic epithelial basement membrane
Author(s) -
ORTONNE J.P.,
HSI B.L.,
VERRANDO P.,
BERNERD F.,
PAUTRAT G.,
PISANI A.,
YEH C.J.G.
Publication year - 1987
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1987.tb04110.x
Subject(s) - basement membrane , basement , medicine , dermatology , chemistry , pathology , history , archaeology
SUMMARY Sera from five patients with clinically and immunopathologically proven herpes gestationis were studied by complement fixing tmmunofluorescence and complement fixing immunoelectron microscopy using specimens of skin, amniochorion and placenta. The resutts demonstrated that the complement fixation antibody (herpes gestationis factor) could bind to the basement membrane zone of skin, amnion and chorion laeve but not to that of the placental syncytiotrophoblast. These data suggest that the herpes gestationis factor may be induced by the basement membrane zone antigens of extra‐villous cytotrophoblasts.