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Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24‐dihydroxycholecalciferol
Author(s) -
KATO T.,
ROKUGO M.,
TERUI T.,
TAGAMI H.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb06237.x
Subject(s) - psoriasis , calcitriol , medicine , vitamin , vitamin d and neurology , cholecalciferol , dermatology , dermatologic agents , endocrinology , chemistry , biochemistry , antibiotics
SUMMARY We treated 11 psoriatic patients with topical 1α, 24‐dihydroxycholecalciferol, a new synthetic analogue of active vitamin D3. In 10 of 15 tests the lesions cleared completely within 1–4 weeks, although some relapses occurred shortly after cessation of treatment. There were no side‐effects. We suggest that 1α, 24(OH)2D3 merits further investigation as a potentially useful topical therapy for psoriasis.