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Immunolocalization of collagenase and tissue inhibitor of metalloproteinases (TIMP) in hypertrophic scar tissue
Author(s) -
HEMBRY ROSALIND M.,
EHRLICH H.P.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb06235.x
Subject(s) - collagenase , matrix metalloproteinase , hypertrophic scar , scars , extracellular , cathepsin , pathology , extracellular matrix , tissue inhibitor of metalloproteinase , interstitial collagenase , immunofluorescence , microbial collagenase , chemistry , biology , medicine , microbiology and biotechnology , immunology , biochemistry , antibody , enzyme
SUMMARY Normal, mature and hypertrophic dermal scars were examined by indirect immunofluorescence for the presence of collagenase, tissue inhibitor of metalloproteinases (TIMP) and cathepsin D. Significant extracellular immunoprecipitation of both collagenase and TIMP were found in areas of all scars judged to be actively remodelling, whereas inactive areas were predominantly negative. TIMP was also present in endothelial cells of patent blood vessels, but found not to be present in the enlarged endothelial cells of occluded vessels. Negligible amounts of extracellular cathepsin D were found.