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Degradation of porcine dermal connective tissue by collagenase and hyaluronidase
Author(s) -
FRIEDMAN K.,
POLLACK S.V.,
MANNING T.,
PINNELL S.R.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb06234.x
Subject(s) - collagenase , hyaluronidase , connective tissue , hairless , microbial collagenase , extracellular matrix , pathology , matrix (chemical analysis) , chemistry , medicine , biochemistry , enzyme , chromatography
SUMMARY Selective destruction of connective tissue may be a useful therapeutic tool in conditions associated with abnormal deposition of scar tissue. We have investigated intradermal injections of clostridial collagenase and bovine testicular hyaluronidase alone and in combination in Yucatan miniature hairless pigs. Collagenase in combination with hyaluronidase was quite efficient at destroying the connective tissue matrix, although elastic tissue appeared to be completely spared. Collagenase alone at higher doses degraded collagen, but hyaluronidase had little effect on connective tissue architecture.