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Treatment of polymorphous light eruption with nicotinamide: a pilot study
Author(s) -
NEUMANN R.,
RAPPOLD E.,
POHLMARKL HELGA
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb06222.x
Subject(s) - nicotinamide , medicine , etiology , dermatology , pellagra , biology , biochemistry , enzyme
SUMMARY In a pilot study, 42 patients suffering from polymorphous light eruption (PLE) were treated with oral nicotinamide, 3 g daily, for 2 weeks. Twenty‐five patients remained free from lesions despite extensive sun exposure. We suggest that an abnormality in tryptophan metabolism is important in the aetiology of PLE, and that nicotinamide administration partially corrects this.