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The in vitro antimicrobial effect of azelaic acid
Author(s) -
LEEMING J.P.,
HOLLAND K.T.,
BOJAR R.A.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb05764.x
Subject(s) - library science , clinical microbiology , medicine , azelaic acid , microbiology and biotechnology , biology , computer science , genetics
SUMMARY Various strains of cutaneous micro‐organisms were tested in vitro for their survival rates in 0.5 mol/1 (8.4% w/v) azelaic acid solution. All bacterial strains exhibited large reductions in viability (at least 40‐fold) over a 24 h test period, but little response was noted with Pityrosporum ovale . The bactericidal effect of azelaic acid was reduced considerably in the presence of nutrients. Minimum inhibitory concentrations (MICs) and minimum bactericidal (or fungicidal) concentrations (MBCs) were also determined. MICs varied from 0.03 mol/1 to 0.25 mol/1; MBCs were all either 0.25 mol/1 or greater.