Premium
Plasminogen activator secreted by cultured human melanocytes
Author(s) -
HASHIMOTO K.,
HORIKOSHI T.,
NISHIOKA K.,
YOSHIKAWA K.,
CARTER D.M.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb05719.x
Subject(s) - plasminogen activator , activator (genetics) , medicine , biology , immunology , microbiology and biotechnology , endocrinology , receptor
SUMMARY A plasminogen activator (PA), M r 72 000, was detected in conditioned medium from human melanocyte cultures by fibrin autography. The electrophoretic mobility was identical to that of tissue PA produced by Bowes melanoma cells. PA activity in human melanocyte culture medium was inhibited by anti‐tissue PA IgG, but not by anti‐urokinase IgG. Our results are the first to show that normal human melanocytes in culture secrete tissue plasminogen activator.