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Immunohistochemical study of lysozyme in lupus miliaris disseminatus faciei
Author(s) -
MIHARA K.,
ISODA M.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb05716.x
Subject(s) - epithelioid cell , lysozyme , giant cell , immunoperoxidase , sarcoidosis , granuloma , pathology , immunohistochemistry , foreign body granuloma , staining , foreign body giant cell , cytoplasm , biology , immunology , medicine , antibody , monoclonal antibody , microbiology and biotechnology , biochemistry
SUMMARY The lysozyme activity in tissue samples from patients with lupus miliaris disseminatus faciei (LMDF), sarcoidosis and foreign body granuloma was investigated using the immunoperoxidase technique. The majority of epithelioid cells and giant cells in LMDF and sarcoidosis showed strong lysozyme staining in their cytoplasm. However, most macrophages and giant cells in foreign body granulomas, including granulomatous reactions to epidermal cysts and other foreign materials, stained weakly for lysozyme or were negative. These results suggest that LMDF is different from the foreign body reaction to inert substances, and may be induced by an immunological mechanism associated with cell‐mediated immunity.