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Exacerbation of pemphigus by rifampicin
Author(s) -
MIYAGAWA S.,
YAMASHINA Y.,
OKUCHI T.,
KONOIKE Y.,
KANO T.,
SAKAMOTO K.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb04882.x
Subject(s) - rifampicin , exacerbation , betamethasone , medicine , pemphigus , pemphigus vulgaris , dermatology , adverse effect , tuberculosis , immunology , pathology
SUMMARY Rifampicin therapy caused exacerbation of skin lesions, rising serum pemphigus antibody titres, and decreased serum betamethasone levels in a 59‐year‐old man with pemphigus vulgaris. Exacerbation of pemphigus was confined to the period of rifampicin therapy and seems to be best explained by the effect of rifampicin on the metabolism of betamethasone. Physicians prescribing rifampicin for the treatment of tuberculosis should be aware of its potential to produce such an important adverse reaction.