Premium
An association between HLA DR1 and lichen planus
Author(s) -
POWELL F.C.,
ROGERS R.S.,
DICKSON E.R.,
MOORE S.BREANNDAN
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb02852.x
Subject(s) - human leukocyte antigen , genetic predisposition , serology , immunology , antigen , medicine , typing , biology , genetics , disease , antibody
SUMMARY Serological typing for HLA Class II antigens in 72 patients with lichen planus (LP) revealed a highly significant association with HLA DR1 and MT1 (DQw1). DR1 was present in 80% of patients with generalized LP, 54% with localized LP, 56% of patients with drug‐induced LP and in 31% of patients with mucosal LP, compared with 25% of normal controls. MT1 (DQw1) was found in 83% of the LP group and 62% of the normal controls. These findings strongly suggest a genetic predisposition or susceptibility to the development of generalized LP and perhaps also to drug‐induced LP.