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Epidermal hyperproliferation following the induction of microabscesses by leukotriene B 4
Author(s) -
BAUER F.W.,
KERKHOF P.C.M.,
GROOD R.M.MAASSENDE
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb02843.x
Subject(s) - leukotriene b4 , stratum corneum , flow cytometry , leukotriene , pathology , chemistry , epidermis (zoology) , immunology , biology , medicine , inflammation , anatomy , asthma
SUMMARY The percentage of non‐diploid epidermal cells was determined by flow cytometry following application of leukotriene B 4 (LTB 4 ) to human skin. Doses in the range 35–500 ng were shown to cause a marked increase in proliferation, the non‐diploid cells reaching a maximum between 72 and 96 h after LTB 4 application. No difference was observed between the response of healthy controls and the uninvolved skin of psoriatic patients. We suggest, therefore, that the hyperproliferation is a consequence of the physical disruption of the stratum corneum accompanying the rupture of microabscesses.