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Morphological changes in peripheral blood cells and skin in amiodarone‐treated patients
Author(s) -
RAPPERSBERGER K.,
KONRAD K.,
WIESER E.,
WEBER H.,
WOLFF K.
Publication year - 1986
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1986.tb02797.x
Subject(s) - amiodarone , medicine , peripheral blood , hyperpigmentation , peripheral , pharmacology , dermatology , atrial fibrillation
SUMMARY Amiodarone, used in the treatment of cardiac arrythmia, may lead to severe discolouration of sun‐exposed skin. The lysosomal storage of a lipid‐like material has been shown to be the morphological substrate for this cutaneous hyperpigmentation. Examination of peripheral white blood cells of amiodarone‐treated patients disclosed identical lysosomal structures indicating that amiodarone treatment leads to a more generalized lysosomal storage of lipids and of amiodarone and its metabolites.