Premium
Inflammatory cell accumulation in response to intracutaneous Paf‐acether: a mediator of acute and persistent inflammation?
Author(s) -
ARCHER C. B.,
PAGE C. P.,
PAUL W.,
MORLEY J.,
MACDONALD D. M.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb15642.x
Subject(s) - extravasation , inflammation , platelet activating factor , mediator , immunology , pathogenesis , histiocyte , medicine , pathology , platelet , endocrinology
SUMMARY The ether‐linked phospholipid, Paf‐acether (AGEPC) is released from a variety of inflammatory cell types and has properties consistent with those of a mediator of inflammation. We have examined the effects of locally administered Paf‐acether on cellular accumulation in the skin of experimental animals and man by histological evaluation of sequential skin biopsies and quantification of accumulation of radiolabelled blood elements. In guinea‐pig skin, immediate extravasation of plasma protein and intravascular accumulation of platelets and neutrophils was succeeded by a persistent mixed cellular infiltrate predominantly of neutrophils but also containing lymphocytes and histiocytes. Radiolabelling studies were consistent with these observations. Intradermal Paf‐acether elicited persistent clinical and histopathological responses in human skin. The finding that Paf‐acether is able to initiate cutaneous cellular accumulation may be important in the pathogenesis of inflammatory dermatoses.