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The Thy‐I epidermal cell: perspective and prospective
Author(s) -
CHAMBERS DONALD A.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb15623.x
Subject(s) - epidermis (zoology) , population , macrophage , immune system , cell , biology , microbiology and biotechnology , in vitro , immunology , cell type , mesenchymal stem cell , pathology , medicine , anatomy , biochemistry , environmental health
SUMMARY Recently a class of cells distinguished by the presence of the cell‐surface protein, Thy‐I, has been discovered in the epidermis. These cells constitute a heterogeneous population such that they may be dendritic or round, and may be derived from both mesenchymal and ectodermal tissue. Phenotypically, cells with the following characteristics have been observed: Thy‐I +, Vim +; Thy‐I+, Vim‐; Thy‐I+, Ker+; Thy‐I+, Ker‐; Thy‐I +, asialo GMI+; Thy‐I +, asialo GMI ‐. Thy‐I + epidermal cells do not appear to be T or B lymphocytes, macrophage/monocytes or melanocytes. The Thy‐I+ epidermal cell can be studied in in vivo and in vitro systems. It would appear that skin as well as the immune system contain Thy‐I+ and Ia + cells. Such cells may he prerequisite for both systems to carry out their primary defense functions.