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Combined features of pemphigus and pemphigoid induced by penicillamine
Author(s) -
VELTHUIS P.J.,
HENDRIKSE J.C.,
NEFKENS J.J.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb15273.x
Subject(s) - bullous pemphigoid , pemphigus , penicillamine , medicine , dermatology , pemphigoid , pemphigus vulgaris , basement membrane , antibody , immunology , pathology
SUMMARY d ‐Penicillamine is able to induce a bullous eruption with the clinical, histological and immunological features of pemphigus. We present a case that had all the characteristics of pemphigus, but also in vivo bound IgG against the dermo‐epidermal junction, i.e. the immunological features of bullous pemphigoid. Since no subepidermal blistering was observed, it is concluded that the penicillamine‐induced auto‐antibodies against the basement membrane zone were biologically inactive.