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Lichen planus pemphigoides‐like lesions induced by cinnarizine
Author(s) -
MIYAGAWA S.,
OHI H.,
MURAMATSU T.,
OKUCHI T.,
SHIRAI T.,
SAKAMOTO K.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb15272.x
Subject(s) - cinnarizine , immunofluorescence , antibody , basement membrane , medicine , pathology , immunology , pharmacology
SUMMARY A 72‐year‐old woman developed a lichen planus pemphigoides‐like eruption following the administration of cinnarizine. The eruption recurred on challenge with the drug. Direct immunofluorescence studies of the lesions demonstrated deposition of IgG, IgM and C 3 on colloid bodies and fibrin at the epidermal basement membrane zone. Circulating IgG antibasement membrane zone antibodies were detected at high titres, with no complement‐ fixing activities. To our knowledge, this is the first report of immunologically defined lichen planus pemphigoides induced by a drug.