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Histocompatibility antigens in plaque psoriasis and palmoplantar pustulosis
Author(s) -
Kemmett D.,
Leigh Irene M.,
Baker H.A.,
McCloskey D.,
Alonso A.,
Awad J.,
Festenstein H.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb13007.x
Subject(s) - psoriasis , human leukocyte antigen , histocompatibility , palmoplantar pustulosis , antigen , immunology , medicine , dermatology , population , genetic predisposition , pustulosis , plaque psoriasis , disease , arthritis , synovitis , environmental health
The inheritance of susceptibility to psoriasis is thought to be multifactorial; expression of the disorder being influenced by environmental factors. Studies of histocompatibility antigens (HLA) help our understanding of the genetic inheritance of susceptibility to the disease. Early HLA studies in chronic plaque psoriasis (CPP) have shown an increased incidence of B13 and B17. More recently the antigens CW6 and DR7 have also been shown to be increased. No statistical increase has been shown in patients with persistent pustular psoriasis of the palms and soles (PPP). However there are limited data on class II antigens in this group. No previous study has compared the two groups of patients in the same population or compared clinical subsets of CPP. Eighty‐five British Caucasian patients with CPP and 45 with PPP were typed for antigens of the HLA A, B, C and DR loci. Our results confirm the increased frequencies of B13, BW57 (B17), Cw6 and DR7 in CPP patients compared with controls, and we have also found a previously unreported decrease in the frequency of BW44 (B12). In contrast the PPP patient group had increased frequencies of B8, Cw7 and DR3. HLA associations of subsets of patients related with family history, age of onset, severity of disease, the presence of arthritis and nail changes have also been assessed.