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Significance of non‐lymphoid (‘accessory’) cells in malignant lymphomas and pseudolymphomas of the skin
Author(s) -
SMOLLE J.,
KAUDEWITZ P.,
BURG G.,
KRESBACH H.,
KERL H.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02403.x
Subject(s) - pseudolymphoma , pathology , histiocyte , lymphoma , germinal center , malignancy , medicine , lymphatic system , b cell , biology , immunology , antibody
SUMMARY We investigated the co‐distribution of lymphocyte subpopulations and non‐lymphoid ‘accessory’ cells in 35 cases of cutaneous lymphoproliferative diseases (T‐cell lymphoma, 10 cases; B‐cell lymphoma, 17 cases; pseudolymphoma, 8 cases) using immunohistochemical methods. T‐zone histiocytes and particularly Langerhans cells were abundant in all cutaneous T‐cell lymphomas, but were also found in B‐cell lymphomas. T‐zone histiocytes were associated with T‐lymphocytes, especially T‐helper cells, but not with T‐suppressor cells. Dendritic reticulum cells were essentially confined to well differentiated germinal centres. Macrophages occurred in both lymphomas and pseudolymphomas without definite relationship with either B‐ or T ‐cells. In malignant lymphomas of high grade malignancy, macrophages represented the only non‐lymphoid cell type. Our results indicate that malignant lymphoid cells, like normal lymphocytes, require definite micro‐environments which are, at least in part, maintained by certain non‐lymphoid cells.