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Tissue plasminogen activator inhibitor in the epidermis
Author(s) -
HASHIMOTO K.,
KATAYAMA I.,
NISHIOKA K.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02375.x
Subject(s) - plasminogen activator , urokinase , epidermis (zoology) , tissue plasminogen activator , activator (genetics) , chemistry , plasminogen activator inhibitor 1 , microbiology and biotechnology , biochemistry , biology , anatomy , endocrinology , receptor , genetics
SUMMARY The presence of a tissue plasminogen activator inhibitor in the epidermis was investigated. A partially purified tissue plasminogen activator from a Bowes melanoma cell line medium was used as a tissue plasminogen activator. Extracts of epidermis dissolved in a 10 mM phosphate buffer, pH 7.0, were found to contain a tissue plasminogen activator inhibitor. The same extracts also contained a urokinase inhibitor. It is not clear whether these inhibitors are the same. This study is the first to show the existence of a tissue plasminogen activator inhibitor in the epidermis.