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The immunobiology of basal cell carcinoma: an in situ monoclonal antibody study
Author(s) -
SYNKOWSKI D.R.,
SCHUSTER PHYLLIS,
ORLANDO J.C.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02358.x
Subject(s) - monoclonal antibody , immunoperoxidase , cytotoxic t cell , cell , t cell , peripheral blood mononuclear cell , basal cell carcinoma , biology , immunology , monoclonal , antibody , basal (medicine) , b cell , microbiology and biotechnology , pathology , immune system , medicine , basal cell , in vitro , endocrinology , biochemistry , insulin
SUMMARY A semi‐quantitative, immunoperoxidase monoclonal antibody technique was used to study the mononuclear cells surrounding 32 basal cell carcinoma specimens from 30 patients. Tumours were analysed in subgroups based on recurrence, size and ulceration. T cell counts were high (>3 out of 4) for all groups while T helper/inducer and T suppressor/cytotoxic cell counts were equal (approx. 2). Macrophage counts were low for all groups, about 1.2, while B cell and Ia positive cell counts were high (>3). T/B cell and T helper/suppressor cell ratios approached one for the tumours as a whole as well as the sub‐groups. The relative importance and contribution of cell mediated vs. humoral immunity in keeping basal cell carcinomas in check is discussed.